Mycophenolate Mofetil in severe or methotrexate refractory localized scleroderma
نویسندگان
چکیده
منابع مشابه
Mycophenolate Mofetil in severe or methotrexate refractory localized scleroderma
Juvenile Localized Scleroderma (JLS), is characterised by presence of areas of skin thickening, which is relatively benign, but if deeper tissues such as muscle and bone are involved severe deformities may develop. Mycophenolate Mofetil (MMF) is increasingly utilised both for treatment of systemic sclerosis and immune-mediated skin diseases such as psoriasis, graft-versus-host and lichen planus...
متن کاملSuccessful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil.
OBJECTIVE To evaluate the efficacy of mycophenolate mofetil (MMF) in the treatment of severe refractory juvenile localized scleroderma (JLS). METHODS A retrospective chart review was performed in patients with JLS who had been treated with MMF after the failure of a combination of MTX and corticosteroids for at least 4 months, or whose JLS had concomitant severe extracutaneous manifestations....
متن کاملMycophenolate mofetil for localized scleroderma
Commentary Systemic sclerosis is one of the rheumatic diseases that is associated with the worst prognosis. Systemic sclerosis is divided into localized and systemic forms. Localized scleroderma comprises four subtypes, namely morphea, generalized morphea, linear scleroderma and en coup de saber, and is more commonly encountered in children. Although conversion into systemic sclerosis is very u...
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The adverse effects of mycophenolate mofetil on the colon are well known. However, isolated small intestinal involvement resulting in diarrhea and severe weight loss is infrequently reported in the literature. We present the case of a 45-year-old woman on mycophenolate mofetil following renal transplant, who presented with abdominal pain and weight loss. An esophagogastroduodenoscopy and colono...
متن کاملThe effectiveness of mycophenolate mofetil in refractory pyoderma gangrenosum.
A 32-year-old white woman with systemic lupus erythematosus presented with a 2-year history of refractory pyoderma gangrenosum on the left pretibial area. The lesion eroded to expose underlying tendons and muscles, and involvement of deep structures caused mononeuritis, with resultant unilateral foot drop and intractable pain. Therapeutic regimens that had been used during this 2-year period bu...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2008
ISSN: 1546-0096
DOI: 10.1186/1546-0096-6-s1-p229